朱家鹏

博士 南京中医药大学 医学院·整合医学学院教授、博士生导师

细胞生物学与医学遗传学系 主任

办公地点：南京市仙林大道138号，B9-302

电话：025-85811079

传真：025-85811078

Email：zhujiapeng@hotmail.com

教育和工作背景

1992年—1996年    南京大学 学士

1996年—1998年    扬州大学 助教

1998年—2002年    北京大学 生物物理学 硕士

2002年—2009年    美国伊利诺伊大学香槟分校 生物化学 博士

2009年—2015年    英国Medical Research Council 博士后

2015年—至今    南京中医药大学 教授

学术奖项与荣誉

2019年 江苏省生物技术创新奖

教学课程与成果

1、生物技术专业导论（本科）

2、医学生物学（本科）

3、医学科研技能与分子技术（研究生）

4、分子生物学技术与技能（研究生）

5、病理学进展（研究生）

6、生物医学进展（研究生）

研究方向与招生

1、中药学（科学学位）

2、生物学（科学学位）

3、中药学（专业学位）

4、生物学（专业学位）

代表性论文：(*共同一作，#共同通讯)

1、Zhu J*, Vinothkumar KR*, Hirst J. Structure of mammalian respiratory complex I. Nature, 2016, 536(7616):354-8.

2、Vinothkumar KR*, Zhu J*, Hirst J. Architecture of mammalian respiratory complex I. Nature. 2014, 515(7525):80-84. 

3、Li J*, Han L*, Vallese F*, Ding Z, Choi SK, Hong S, Luo Y, Liu B, Chan CK, Tajkhorshid E, Zhu J^#, Clarke O^#, Zhang K^#, Gennis R^#. Cryo-EM structures of Escherichia coli cytochrome bo3 reveal bound phospholipids and ubiquinone-8 in a dynamic substrate binding site. Proc Natl Acad Sci U S A. 2021, 118(34): e2106750118. 

4、Xu J*, Ding Z*, Liu B*, Yi SM, Li J, Zhang Z, Liu Y, Li J, Liu L, Zhou A, Gennis RB, Zhu J. Structure of the cytochrome aa 3-600 heme-copper menaquinol oxidase bound to inhibitor HQNO shows TM0 is part of the quinol binding site. Proc Natl Acad Sci U S A. 2019, 117(2):872-876. 

5、Zhu J, King MS, Yu M, Klipcan L, Leslie AG, Hirst J. Structure of subcomplex Iβ of mammalian respiratory complex I leads to new supernumerary subunit assignments. Proc Natl Acad Sci U S A. 2015, 112(39):12087-92. 

6、Lu J*, Li J*, Wu Y, Fang X, Zhu J^#, Wang H^#. Characterization of the FMN-Dependent Cysteine Decarboxylase from Thioviridamide Biosynthesis. Org Lett. 2019, 21(12):4676-4679. 

7、Wang YS, Zhang B, Zhu J^#, Yang CL, Guo Y, Liu CL, Liu F, Huang H, Zhao S, Liang Y, Jiao RH, Tan RX^#, Ge HM^#. Molecular Basis for the Final Oxidative Rearrangement Steps in Chartreusin Biosynthesis. J Am Chem Soc. 2018, 140(34):10909-10914.

8、Liu Y, Liu F, Liang W, Zhu L, Lantz RC, Zhu J^#, Chen Y^#. Arsenic represses airway epithelial mucin expression by affecting retinoic acid signaling pathway. Toxicol Appl Pharmacol. 2020, 394:114959. 

9、Jiang F, Hu Q, Zhang Z, Li H, Li H, Zhang D, Li H, Ma Y, Xu J, Chen H, Cui Y, Zhi Y, Zhang Y, Xu J, Zhu J^#, Lu T^#, Chen Y^#. Discovery of Benzo[cd]indol-2(1H)-ones and Pyrrolo[4,3,2-de]quinolin-2(1H)-ones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain with Potential High Efficiency against Acute Gouty Arthritis. J Med Chem. 2019, 62(24):11080-11107. 

10、Zhang Z, Xu J, Liu B, Chen F, Li J, Liu Y, Zhu J^#, Shen C^#. Ponicidin inhibits pro-inflammatory cytokine TNF-α-induced epithelial-mesenchymal transition and metastasis of colorectal cancer cells via suppressing the AKT/GSK-3β/Snail pathway. Inflammopharmacology. 2019, 27(3):627-638. 

11、Li J*, Zou W*, Yu K, Liu B, Liang W, Wang L, Lu Y, Jiang Z, Wang A^#, Zhu J^#. Discovery of the natural product 3',4',7,8-tetrahydroxyflavone as a novel and potent selective BRD4 bromodomain 2 inhibitor. J Enzyme Inhib Med Chem. 2021, 36(1):903-913.

12、Chen F*, Chen L*, Liang W, Zhang Z, Li J, Zheng W, Zhu Z, Zhu J^#, Zhao Y^#. Identification and confirmation of 14-3-3 ζ as a novel target of ginsenosides in brain tissues. J Ginseng Res. 2021, 45(4):465-472.

13、Kong B, Zhu Z, Li H, Hong Q, Wang C, Ma Y, Zheng W, Jiang F, Zhang Z, Ran T, Bian Y, Yang N, Lu T, Zhu J^#, Tang W^#, Chen Y^#. Discovery of 1-(5-(1H-benzo[d]imidazole-2-yl)-2, 4-dimethyl-1H-pyrrol-3-yl) ethan-1-one derivatives as novel and potent bromodomain and extra-terminal (BET) inhibitors with anticancer efficacy. Eur J Med Chem. 2021, 227:113953.

14、Zhu J, Han H, Pawate A, Gennis RB. Decoupling mutations in the D-channel of the aa(3)-type cytochrome c oxidase from Rhodobacter sphaeroides suggest that a continuous hydrogen-bonded chain of waters is essential for proton pumping. Biochemistry. 2010, 49(21):4476-82.

15、Zhang B, Wang KB, Wang W, Wang X, Liu F, Zhu J, Shi J, Li LY, Han H, Xu K, Qiao HY, Zhang X, Jiao RH, Houk KN, Liang Y, Tan RX, Ge HM. Enzyme-catalysed [6+4] cycloadditions in the biosynthesis of natural products. Nature. 2019, 568(7750):122-126.